It may be because of my recent enjoyment of it but.. I'll say Portal. Specifically Portal 2. Some games can't even make humans sounds emotional. This one has robot/computer voices with obvious sarcasm, fear, anger and sometimes...loveeeee
Alundra.... While the first game had a very interesting plot and great character development, dreams, vampires, drama and all in one town! The second game went with pirates and puzzles. It was terrible (>_<)
I know you're probably tired of seeing this one in my responses but...Not only does this game have emotional significance for me the story is amazing. Time Travel, Magical Kingdoms, the power to change the world! Of course my choice is...